Triple Negative Breast Cancer (TNBC) constitutes 10 to 15% of breast cancer diagnoses. TNBC is more prevalent among younger individuals, African Americans, and Hispanics. This unique form of breast cancer lacks three receptors commonly found in breast cancer cells, posing specific challenges for treatment. The name “Triple-negative” is derived from the omission of these three receptors that are commonly found in breast cancer cells: estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2). Here, we explore what TNBC is, how it is diagnosed and treated, and delve into the unique challenges it presents. Despite these challenges, there are also silver linings and sources of hope for those on this complex journey.